{"id":22556,"date":"2026-04-30T15:16:08","date_gmt":"2026-04-30T12:16:08","guid":{"rendered":"https:\/\/www.pasteur.mg\/?p=22556"},"modified":"2026-04-30T16:32:09","modified_gmt":"2026-04-30T13:32:09","slug":"cloture-de-la-formation-dediee-au-sequencage-et-analyses-bioinformatiques-appliques-au-virus-mpox-un-renforcement-des-capacites-en-surveillance-genomique-a-madagascar","status":"publish","type":"post","link":"https:\/\/www.pasteur.mg\/en\/cloture-de-la-formation-dediee-au-sequencage-et-analyses-bioinformatiques-appliques-au-virus-mpox-un-renforcement-des-capacites-en-surveillance-genomique-a-madagascar\/","title":{"rendered":"Cl\u00f4ture de la formation d\u00e9di\u00e9e au s\u00e9quen\u00e7age et analyses bioinformatiques appliqu\u00e9s au virus Mpox\u00a0; un renforcement des capacit\u00e9s en surveillance g\u00e9nomique \u00e0 Madagascar"},"content":{"rendered":"

L\u2019Institut Pasteur de Madagascar (IPM), \u00e0 travers son Unit\u00e9 de Virologie, a organis\u00e9 du 20 au 29 avril 2026, une formation d\u00e9di\u00e9e au s\u00e9quen\u00e7age et aux analyses bio-informatiques appliqu\u00e9s au virus Mpox.<\/p>\n

Au total, la formation a accueilli 6 participants, dont 3 du Laboratoire d\u2019Analyses M\u00e9dicales Malagasy (LA2M), 2 du Centre d\u2019Infectiologie Charles M\u00e9rieux (CICM) et 1 de l\u2019ONG Pivot, aux c\u00f4t\u00e9s de l\u2019\u00e9quipe de l\u2019Unit\u00e9 de Virologie de l\u2019IPM, mobilis\u00e9e pour l\u2019encadrement et la mise en \u0153uvre du programme. Cette participation illustre une mobilisation conjointe des acteurs impliqu\u00e9s dans la surveillance et la recherche en sant\u00e9 publique \u00e0 Madagascar.<\/p>\n

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Structur\u00e9e en deux volets compl\u00e9mentaires, la formation a combin\u00e9 une phase de laboratoire consacr\u00e9e aux techniques de s\u00e9quen\u00e7age \u2013 incluant la s\u00e9lection des \u00e9chantillons, l\u2019amplification, la pr\u00e9paration des librairies et l\u2019utilisation de logiciels sp\u00e9cialis\u00e9s \u2013 et une phase d\u00e9di\u00e9e aux analyses bio-informatiques. Cette derni\u00e8re a port\u00e9 sur les bases des lignes de commande, la gestion et l\u2019interpr\u00e9tation des donn\u00e9es de s\u00e9quen\u00e7age, la construction de s\u00e9quences consensus et la g\u00e9n\u00e9ration d\u2019arbres phylog\u00e9n\u00e9tiques.<\/p>\n

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L\u2019ensemble de ces enseignements a permis aux participants d\u2019acqu\u00e9rir une compr\u00e9hension int\u00e9gr\u00e9e de la cha\u00eene de production et d\u2019analyse des donn\u00e9es g\u00e9nomiques, depuis la g\u00e9n\u00e9ration des s\u00e9quences jusqu\u2019\u00e0 leur exploitation dans une perspective de surveillance g\u00e9nomique.<\/p>\n

Dans un contexte marqu\u00e9 par l\u2019\u00e9mergence et la circulation du virus Mpox \u00e0 Madagascar, le d\u00e9veloppement de comp\u00e9tences en g\u00e9nomique virale constitue un enjeu strat\u00e9gique. La surveillance g\u00e9nomique permet en effet de mieux caract\u00e9riser les souches virales, de suivre leur \u00e9volution, de mieux comprendre les dynamiques de transmission et d\u2019appuyer les strat\u00e9gies vaccinales, contribuant ainsi \u00e0 orienter les r\u00e9ponses en sant\u00e9 publique. L\u2019impl\u00e9mentation de la surveillance g\u00e9nomique des pathog\u00e8nes \u00e0 potentiel \u00e9pid\u00e9mique et pand\u00e9mique est d\u00e9sormais recommand\u00e9e par l\u2019OMS dans le cadre de la pr\u00e9paration aux \u00e9pid\u00e9mies et pand\u00e9mies futures.<\/p>\n

Au-del\u00e0 du renforcement des capacit\u00e9s individuelles, cette formation a \u00e9galement favoris\u00e9 les \u00e9changes techniques et scientifiques entre les \u00e9quipes de l\u2019IPM, du LA2M, du CICM et de l\u2019ONG Pivot, contribuant \u00e0 une meilleure coordination des acteurs impliqu\u00e9s dans la surveillance des maladies infectieuses. C\u2019est une premi\u00e8re activit\u00e9 entrant dans le cadre de l\u2019accord de collaboration (MoU) r\u00e9cemment sign\u00e9 entre l\u2019IPM, le LA2M et le CICM.<\/p>\n

\"\"<\/p>\n

La formation s\u2019est achev\u00e9e par une remise de certificats aux participants, marquant la reconnaissance de leur engagement et des comp\u00e9tences acquises.<\/p>\n

\u00c0 travers cette initiative, l\u2019IPM r\u00e9affirme son engagement \u00e0 soutenir le d\u00e9veloppement des comp\u00e9tences nationales et \u00e0 renforcer les dispositifs de surveillance des maladies infectieuses, en collaboration avec ses partenaires, en t\u00e9moigne la premi\u00e8re publication dans une revue scientifique sur l\u2019\u00e9mergence du virus Mpox \u00e0 Madagascar\u00a0: \u00ab Emergence of human monkeypox virus Clade Ib in Madagascar: first genomic evidence of introduction and local transmission.<\/em>\u00a0\u00bb https:\/\/doi.org\/10.1186\/s12985-026-03165-7<\/a>. Cette premi\u00e8re \u00e9tude a \u00e9t\u00e9 r\u00e9alis\u00e9e en collaboration avec le LA2M.<\/p>\n

\u00c0 l\u2019issue de la formation, RAKOTOARISON Rado Lalaina, biotechnologiste au sein du LA2M a affirm\u00e9 \u00ab\u00a0j\u2019ai acquis des comp\u00e9tences directement applicables \u00e0 mon travail au LA2M, notamment en mati\u00e8re de bonnes pratiques de s\u00e9quen\u00e7age et de manipulation. J\u2019ai \u00e9galement renforc\u00e9 mes bases en bio-informatique. D\u00e9sormais, je me sens capable de r\u00e9aliser des s\u00e9quen\u00e7ages de mani\u00e8re plus autonome et de t\u00e9l\u00e9charger des s\u00e9quences afin de mettre en pratique les acquis de la formation<\/em>.\u00bb<\/p>\n

\"\"<\/p>\n

Pour l\u2019\u00e9quipe formatrice, Dr Jean Michel HERAUD, chef de l\u2019Unit\u00e9 de Virologie de l\u2019IPM revient sur l\u2019int\u00e9r\u00eat de cette formation pour la surveillance des pathog\u00e8nes d\u2019int\u00e9r\u00eat en sant\u00e9 publique\u00a0: \u00ab\u00a0l\u2019Unit\u00e9 de Virologie a pour strat\u00e9gie, le renforcement des capacit\u00e9s de s\u00e9quen\u00e7age et d\u2019analyse bio-informatique non seulement au niveau de l\u2019IPM, mais aussi au niveau du pays. Ce type de surveillance permet de caract\u00e9riser plus finement les pathog\u00e8nes viraux pouvant causer des \u00e9pid\u00e9mies voir des pand\u00e9mies. Le renforcement des comp\u00e9tences nationales en surveillance g\u00e9nomique est un atout pour Madagascar et s\u2019int\u00e8gre dans les activit\u00e9s de surveillance et de riposte aux \u00e9pid\u00e9mies.<\/em>\u00a0\u00bb<\/p>\n

Voir aussi les publications sur les r\u00e9seaux sociaux<\/strong><\/em>
\nOuverture de la formation : Facebook<\/a> – Linkedin<\/a>
\nCl\u00f4ture de la formation : Facebook<\/a> – Linkedin<\/a><\/p>","protected":false},"excerpt":{"rendered":"

L\u2019Institut Pasteur de Madagascar (IPM), \u00e0 travers son Unit\u00e9 de Virologie, a organis\u00e9 du 20 au 29 avril 2026, une formation d\u00e9di\u00e9e au s\u00e9quen\u00e7age et aux analyses bio-informatiques appliqu\u00e9s au virus Mpox. Au total, la formation a accueilli 6 participants, dont 3 du Laboratoire d\u2019Analyses M\u00e9dicales Malagasy (LA2M), 2 du Centre d\u2019Infectiologie Charles M\u00e9rieux (CICM) […]<\/p>","protected":false},"author":23,"featured_media":22558,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","jetpack_post_was_ever_published":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[7,616],"tags":[],"class_list":["post-22556","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites","category-controle-des-maladies-infectieuses"],"acf":[],"yoast_head":"\nCl\u00f4ture de la formation d\u00e9di\u00e9e au s\u00e9quen\u00e7age et analyses bioinformatiques appliqu\u00e9s au virus Mpox\u00a0; 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