{"id":22877,"date":"2026-07-13T10:24:15","date_gmt":"2026-07-13T07:24:15","guid":{"rendered":"https:\/\/www.pasteur.mg\/?p=22877"},"modified":"2026-07-13T11:31:04","modified_gmt":"2026-07-13T08:31:04","slug":"mpox-en-afrique-lancement-dun-essai-clinique-a-madagascar","status":"publish","type":"post","link":"https:\/\/www.pasteur.mg\/en\/mpox-en-afrique-lancement-dun-essai-clinique-a-madagascar\/","title":{"rendered":"Mpox en Afrique\u00a0: lancement d\u2019un essai clinique \u00e0 Madagascar"},"content":{"rendered":"

Suite \u00e0 la d\u00e9claration de de l\u2019\u00e9pid\u00e9mie de variole du singe (mpox) \u00e0 Madagascar, les repr\u00e9sentantes de l\u2019ONG PANTHER, sont venues en f\u00e9vrier 2026, discuter de la faisabilit\u00e9 de l\u2019\u00e9tude MOSA dans le pays, avec les membres de l\u2019Institut Pasteur de Madagascar (IPM).<\/p>\n

L\u2019essai clinique MOSA, (MpOx Study in Africa<\/em>) \u00e0 Madagascar, premier essai plateforme adaptatif d\u2019investigation clinique panafricaine d\u00e9di\u00e9 aux traitements contre la mpox est une \u00e9tude en double aveugle, avec un bras contr\u00f4le, placebo. L\u2019\u00e9tude est supervis\u00e9e par un comit\u00e9 de pilotage international pr\u00e9sid\u00e9 par le d\u00e9partement Science et Innovation de Africa CDC. Pour l\u2019instant un seul traitement est en \u00e9valuation pour son efficacit\u00e9 et sa s\u00e9curit\u00e9, brincidofovir (commercialis\u00e9 sous le nom de TEMBEXA\u00ae, pour d\u2019autres indications), un antiviral d\u00e9velopp\u00e9 par l\u2019entreprise biopharmaceutique sp\u00e9cialis\u00e9e dans les sciences de la vie et la sant\u00e9 publique, Emergent BioSolutions. D\u2019autres mol\u00e9cules pourraient y \u00eatre test\u00e9es, notamment issues de la recherche scientifique continentale.<\/p>\n

La mise en place du site clinique a \u00e9t\u00e9 r\u00e9alis\u00e9e les 23 et 24 avril 2026, en collaboration avec les \u00e9quipes du CHU Andohatapenaka \u00e0 Antananarivo.<\/p>\n

Le premier patient a \u00e9t\u00e9 inclus le 22 mai 2026.<\/p>\n

Ce projet a d\u00e9j\u00e0 d\u00e9but\u00e9 en R\u00e9publique D\u00e9mocratique du Congo depuis janvier 2025 sous la supervision du l\u2019Institut de Recherche Biom\u00e9dicale et de l\u2019Institut National de Sant\u00e9 Publique.<\/p>\n

Ce projet a \u00e9t\u00e9 d\u00e9velopp\u00e9 par l\u2019ONG PANTHER. L\u2019essai MOSA b\u00e9n\u00e9ficie d\u2019un financement du programme recherche et innovation Horizon Europe de l\u2019Union Europ\u00e9enne (num\u00e9ro de subvention : 101115188), ainsi que de fonds suppl\u00e9mentaires d\u2019Africa CDC et Emergent BioSolutions (https:\/\/investors.emergentbiosolutions.com\/news-releases\/news-release-details\/emergent-biosolutions-and-panther-announce-agreement-support).<\/p>\n

Cet essai men\u00e9 par les chercheurs de l\u2019IPM (Unit\u00e9s d\u2019Epid\u00e9mie et Recherche Clinique ainsi que de Virologie) et du Centre Hospitalier Universitaire d\u2019Andohatapenaka illustre le leadership de l\u2019Afrique dans la recherche et une avanc\u00e9e d\u00e9terminante pour \u00e9tudier le r\u00f4le du brincidofovir dans la prise en charge de la mpox dont les r\u00e9sultats pourront servir aux populations \u00e0 risque.<\/p>\n

Les informations de prescription approuv\u00e9es par la FDA am\u00e9ricaine pour TEMBEXA\u00ae (brincidofovir) sont fournies ici \u00e0 titre d\u2019informations compl\u00e9mentaires sur la s\u00e9curit\u00e9. Microsoft Word – TEMBEXA USPI Final.docx<\/a><\/p>\n

En savoir plus sur l\u2019essai MOSA:<\/p>\n

\u00a0https:\/\/africacdc.org\/news-item\/enrollment-starts-in-africa-cdc-led-mpox-therapeutic-study-mosa\/<\/a><\/p>\n

\"\"<\/p>\n

——————————————————–<\/p>\n

MOSA project communication \u2013 Institut Pasteur de Madagascar<\/strong><\/p>\n

Mpox in Africa: launch of a clinical trial in Madagascar<\/strong><\/p>\n

Following the declaration of the monkeypox (mpox) outbreak in Madagascar, representatives of the NGO PANTHER visited in February 2026 to discuss the feasibility of the MOSA study in the country with members of the Institut Pasteur de Madagascar (IPM).<\/p>\n

The MOSA clinical trial (MpOx Study in Africa<\/em>) in Madagascar, the first pan-African adaptive platform clinical investigation trial dedicated to mpox treatments, is a double-blind, placebo-controlled study. The study is overseen by an international steering committee chaired by the Science and Innovation Department of Africa CDC. At present, only one treatment is being evaluated for its efficacy and safety in mpox: brincidofovir (brand name TEMBEXA\u00ae in other indications), an antiviral developed by the global life sciences and public health company Emergent BioSolutions. Other molecules may also be tested as part of the trial, including compounds arising from continental scientific research.<\/p>\n

The clinical site was set up on 23 and 24 April 2026 in collaboration with the teams of CHU Andohatapenaka in Antananarivo.<\/p>\n

The first patient was enrolled on 22 May 2026.<\/p>\n

This project has already been underway in the Democratic Republic of the Congo since January 2025 under the supervision of the Institut de Recherche Biom\u00e9dicale and the Institut National de Sant\u00e9 Publique.<\/p>\n

This project was developed by the NGO PANTHER. The MOSA trial benefits from funding from the European Union\u2019s Horizon Europe research and innovation program (under grant number: 101115188), as well as additional funding from Africa CDC and Emergent BioSolutions (https:\/\/investors.emergentbiosolutions.com\/news-releases\/news-release-details\/emergent-biosolutions-and-panther-announce-agreement-support).<\/p>\n

This trial, led by researchers from IPM (Epidemiology and Clinical Research Units, as well as the Virology Unit) and the Andohatapenaka University Hospital Centre, illustrates Africa\u2019s leadership in research and marks a decisive step forward in investigating the role of brincidofovir in mpox management, with results that may benefit at-risk populations.<\/p>\n

The U.S. FDA Prescribing Information for TEMBEXA\u00ae (brincidofovir) is provided for additional safety information. \u00a0Microsoft Word – TEMBEXA USPI Final.docx<\/a><\/p>\n

Learn more about the MOSA trial: https:\/\/africacdc.org\/news-item\/enrollment-starts-in-africa-cdc-led-mpox-therapeutic-study-mosa\/<\/a><\/p>\n

Voir aussi
\nFacebook<\/a>
\nLinkedin<\/a><\/p>","protected":false},"excerpt":{"rendered":"

Suite \u00e0 la d\u00e9claration de de l\u2019\u00e9pid\u00e9mie de variole du singe (mpox) \u00e0 Madagascar, les repr\u00e9sentantes de l\u2019ONG PANTHER, sont venues en f\u00e9vrier 2026, discuter de la faisabilit\u00e9 de l\u2019\u00e9tude MOSA dans le pays, avec les membres de l\u2019Institut Pasteur de Madagascar (IPM). L\u2019essai clinique MOSA, (MpOx Study in Africa) \u00e0 Madagascar, premier essai plateforme […]<\/p>","protected":false},"author":23,"featured_media":22878,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[7,616],"tags":[],"class_list":["post-22877","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites","category-controle-des-maladies-infectieuses"],"acf":[],"yoast_head":"\nMpox en Afrique\u00a0: lancement d\u2019un essai clinique \u00e0 Madagascar - Institut Pasteur de Madagascar<\/title>\n<meta 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